The Press-Dispatch
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Loans are offered in amounts of $500, $750, $1250 or $3000. Approval and loan amount based on expected refund amount, ID verification, eligibility criteria, and underwriting. If approved, funds will be loaded on a prepaid card and the loan amount will be deducted from your tax refund, reducing the amount that is paid directly to you. Tax returns may be e-filed without applying for this loan. Fees for other optional products or product features may apply. Limited time offer. Available at participating locations. Not offered in Puerto Rico. HRB Maine License No.: FRA2. See hrblock.com/refundadvance for details. ©2017 HRB Tax Group, Inc. hrblock.com/refundadvance 18-449 200 N 6TH Street, Petersburg, IN 47567 | 812-354-6532 MAKE AN APPOINTMENT TODAY. *This is an optional tax refund-related loan from BofI Federal Bank, Member FDIC; it is not your tax refund. Loans are offered in amounts of $500, $750, $1250 or $3000. Approval and loan amount based on expected refund amount, ID verification, eligibility criteria, and underwriting. If approved, funds will be loaded on a prepaid card and the loan amount will be deducted from your tax refund, reducing the amount that is paid directly to you. Tax returns may be e-filed without applying for this loan. Fees for other optional products or product features may apply. Limited time offer. Available at participating locations. Not offered in Puerto Rico. HRB Maine License No.: FRA2. 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Nichols Ave., Petersburg 812-698-1428 MOOSE LODGE Dining Specials 5pm-8pm 115 Pike Ave., Petersburg WILL RE-OPEN: FRIDAY FEBRUARY 9 CLOSED FOR REPAIRS A popular tool for drug discovery just got 10 times faster By Kayla Zacharias Purdue News Service kzachar@purdue.edu Cooks DESI Laboratory manager Larisa Avramova operates a robotic fluid han- dling system used to spot chemical reactions in plates to be analyzed by DESI-MS. Download image Researchers at Purdue University just made high throughput screening, a pro- cess often used in drug dis- covery, 10 times faster than previous methods. "The area of high- throughput library screen- ing reached a plateau, where the fastest screens took about eight seconds per tar- get," said Graham Cooks, the Henry B. Hass Distin- guished Professor of An- alytical Chemistry at Pur- due, who led the research. "If you can reduce that time by a factor of ten, which is what we're reporting, then you can potentially do li- brary screens that might have taken months in days." High-throughput screen- ing uses robotics, data pro- cessing software, liquid han- dling devices and sensitive detectors to quickly conduct millions of chemical, genetic and pharmacological tests. It allows researchers to iden- tify active compounds, anti- bodies or genes that mod- ulate a particular biomo- lecular pathway, which is especially useful for drug discovery. Cooks' lab combined de- sorption electrospray ion- ization (DESI) mass spec- trometry, a method of mak- ing ions from solid samples, with robotic sampling tech- nologies to create a faster screening process. The re- search was published in the journal Chemical Science. DESI, which was origi- nally developed for biolog- ical tissue imaging, sprays electrically charged drop- lets at a sample, from which ions are generated and then collected and analyzed in a standard mass spectrome- ter. This method was also developed in Cooks' lab at Purdue. "We are spraying a sol- vent onto a mixture and cre- ating a new product, which we're seeing in a splashed droplet," Cooks said. Cooks screening Graph- ic abstract showing high throughput analysis of re- action mixture arrays us- ing methods that were orig- inally developed for biolog- ical tissue imaging. Down- load image This technique allows re- searchers to perform a reac- tion and analyze the product in one step, in one second. That's the power of it, Cooks said. The research was sup- ported by the Defense Ad- vanced Research Project Agency's Make-It! program, which aims to develop tech- nology to create any particu- lar chemical from cheap raw materials. Five research in- stitutions are involved in the program, and Purdue's task is to develop methods to rap- idly analyze the results of re- agents being mixed together under particular conditions. The project's objective is essentially to rationalize or- ganic synthesis. "How do you do that? You have to create some ac- cessible knowledge base, which says that if you com- bine sample A with sample B you will get sample C," Cooks said. "There's an al- gorithmic knowledge base that needs to be construct- ed, and then there's the con- ditions under which particu- lar reagents are examined. So it's not only the reagents, it's also the solvents, the cat- alysts, the physical condi- tions that we're looking at." The current methods for designing and producing new synthetic molecules can take years between ini- tial design and final produc- tion. Increasing the rate of discovery and production of molecules could lead to ad- vances in several areas cru- cial to national security, ac- cording to DARPA. Laboratory manager Larisa Avramova operates a robotic fluid handling sys- tem used to spot chemical reactions in plates to be analyzed by DESI-MS. New nurse practitioner at Gibson General Nurse practitioner Tabitha Newman, center, joins Dr. Clark, left, and Dr. Wells, in practice at Gibson General Hospital.