The Press-Dispatch
Issue link: https://www.ifoldsflip.com/i/103825
The Press-Dispatch B-5 Wednesday, January 16, 2013 Scientist studies DNA repair; hopes to improve breast cancer treatment By: Elizabeth K. Gardner A Purdue University scientist is studying the way cells repair damaged DNA in the hopes of making cancer cells more susceptible to treatment and normal tissue better able to withstand it. The National Institutes of Health recognized PierreAlexandre Vidi and his research with a Howard Temin Pathway to Independence Award in Cancer for highly promising postdoctoral research scientists. This is the first time a postdoctoral researcher has received the award while at Purdue. The National Cancer Insti- tute issued the award to 60 researchers in the United States in 2012. Vidi uses a 3-D cell culture to reproduce mammary glands and breast cancers with the architecture they would have within the human body. He then studies how cells' organization and interactions influence the process of DNA repair. "Our ultimate goal is to improve cancer treatment and the quality of life of cancer patients," Vidi said. "We want to learn how to make cancer cells less able to repair themselves after chemotherapy or radiation treatment. This could reduce treatment doses and the debilitating side effects of those treatments— the patients must endure." A better understanding of what influences DNA repair could also lead to strategies to boost DNA repair in normal cells and prevent cancer initiation, he said. Vidi's findings suggest that tissue architecture influences the organization of the cell nucleus and nuclear processes such as DNA repair. He will use the grant to further investigate the underlying mechanisms and how the organization of normal and cancer cells influences the flow of information that leads to DNA repair. Vidi's research approach differs from most other cancer researchers due to the inclusion of healthy tissue models in parallel to cancers in his studies. He credits his mentor, Sophie Lelièvre, as a leader of this approach. Lelièvre is an associate professor of basic medical sciences in Purdue's College of Veterinary Medicine and associate director of discovery groups in the Purdue Center for Cancer Research. "Her laboratory is famous for approaching cancer research by first understand- ing normal tissue behavior," Vidi said. "Dr. Lelièvre's group also is one of the few in the world able to reproduce the complex organization of cells that line the mammary ducts and create 3-D cell culture models." Vidi's Pathway to Independence Award comes through the National Cancer Institute at the NIH. The competitive award was created in 2007 and provides five years of support comprising two years of mentored support as a postdoctoral fellow followed by three years of support as an independent researcher. In addition to Le- lièvre, Vidi's mentors include Joseph Irudayaraj from Purdue's School of Agricultural and Biological Engineering and Tom Misteli from the National Cancer Institute. "Pierre's training and the mentors he has sought bridge expertise in cancer biology and in biophysical technologies that are the future of this field," said Lelièvre, who also leads the International Breast Cancer and Nutrition Project. "He shows tremendous promise as a scientist and cancer researcher and carries the torch of our laboratory's values." Memorial Hosp. presented Outstanding Little Company of Mary Physician Award Memorial Hospital and Health Care Center will begin presenting an annual Outstanding Little Company of Mary Physician Award to a deserving physician in 2013. This award is named after the Sisters of the Little Company of Mary, the sponsors of Memorial Hospital and Health Care Center. The award is based on outstanding job performance reflecting Memorial Hospital's Mission Statement and the Core Values of Respect for Human Dignity, Compassionate Caring, Stewardship, Quality and Justice. To be accepted as a nominee, a phy- sician must be classified as a member of the hospital's Active Medical Staff for a minimum of twelve months and be in good standing with the Medical Staff. The nomination process begins with any individual, i.e. patient, community member, hospital employee, physician, etc., completing and submitting a nomination form to Michele Rose, Medical Staff Coordinator at Memorial Hospital, by January 25. All nominations will be reviewed by the hospital's Mission Committee, and the top six nominees sent for review to the Selection Committee, consisting of the hospital's Medical Staff Officers, the Executive Director of Mission Integration, and the Vice President of Patient Services/ Chief Nursing Officer. The Outstanding LCM Physician Award will be presented by the Medical Staff President during the hospital's Medical 5730 N State Road 57, Petersburg 1014 N West Dr, Oakland City new listing! Quality constructed brick family home with full finished basement, two baths, three bedrooms, a two car attached garage and a one and a half car detached garage on an almost one acre lot. Recently remodeled home with a new roof, new windows, a newer high efficiency furnace, a fireplace, newer water heater and many updates. MLS# 196090 $154,900 Staff Appreciation Banquet. For more information or to receive a nomination form, contact Michele Rose, Medical Staff Coordinator, at 9960675 or mrose@mhhcc.org, or log onto the hospital's website at www.mhhcc.org to download the nomination form. 612 S Hickory Ln, Petersburg price reduced! Well built three bedroom/two bath home with a lot of open space including a large living room, family room and a huge sun porch. It includes a two car attached garage and an outbuilding. Many updates and obviously well cared for. Very nice yard in a great neighborhood in the Eastwood subdivision. MLS#194903 Almost 2,300 square feet with 4 bedrooms, 2 1/2 baths plus a two car attached garage and a breezway to a two car detached garage. 1 1/2 acres just north of Petersburg contiguous to the Lake Minnis subdivision. The tri-level home has a large living room a big kitchen, dining room, small salon, and laundry on the main level. MLS#189978 $129,900 $144,900 commercial / multi-unit 1004 E. Illinois St., Petersburg 796 W CR 125 S, Petersburg Country and quiet. Nice home on 7.59 acres filled with pond and trees. This property is near the Patoka Wildlife area and not far from Sugar Ridge. The house includes a large family room (28' x 14'9), two bedrooms, functional kitchen, dining room, laundry and bath. MLS#188345 $99,900 436 E 1st St., Lynnville Easy to care for, neat, well kept, smaller home, two bedroom, one bath, plus office/ den/workout room, open kitchen and good size living room. Located on a nice quiet street in Lynnville. Call Joe Schitter at 449-6469 MLS#186663 $79,900 1064 S State Road 61, Petersburg Three bedroom brick ranch in Campbelltown with basement, attached garage, two detached garages and an above ground pool on 3/4s of an acre with partial fenced in yard. Nice setting, great location! MLS#193941 $94,900 1005 E Porter St., Winslow Very nice, well kept home with basement two car detached garage, and a second storage garage. Lots of room for a two bedroom house. Large rooms and a lot of space. A beautiful second lot is attached with the house. MLS#190374 $79,900 16,200 square foot former grocery building on 2.5 acres in a great location. This intersection is the gateway to Petersburg. Several more acres are available if needed. 1193 E CR 400 N, Petersburg Large, nice, triple-wide manufactured home with a 48' x 24' detached garage with work shop and concrete floor on about an acre near Prides Creek Park. Three bedrooms, two full baths, a large living room and a family room as well as an open kitchen and dining. Well taken care of, large front yard and modestly priced. MLS#194776 $92,900 1613 Harding Ave, Evansville Very nice well maintained home in a great location. Home features a front room that would be perfect as an office/den. The backyard is very private and fenced-in. The detached garage is very large with three overhead doors. You're gonna love it! Call Darron Albin at 483-6708 MLS#193240 $78,900 MLS#179830 409 E Main St., Petersburg A great Main Street location in the heart of downtown. A 30'x70' building on an 80'x105' lot. Traditionally a service station but could have multiple uses. Currently has three bays, 24'x18', 29'x14' & 29'x16' with a 18.5'x16' office. MLS#187377 8205 Industrial Park Dr, P'burg Former Ames Handle factory. Over 10,000 SF under roof. All steel construction with 30 inch support beams, well insulated on 13.39 acres. Includes 6 inch water main, and three 200 HP electrical services. MLS#175795 $199,000 104 S Bluff Street, Winslow 508 S 10th Street, Petersburg new listing! Remodeled home with many new features: self contained heating and air unit, cabinets, bathroom, flooring, plumbing, electrical, windows and more! Nice smaller home with little maintenance. One large bedroom down stairs and a bedroom upstairs. MLS# 186074 Remodeled and updated three bedroom, two bath manufactured home in a quiet part of town. Total electric but includes a comfy wood burning fireplace in the family room. Many special touches including large and lots of closets, handicap accessible, huge pantry, built in stereo and handrails. Updates include metal roof, new toilets, new sink and counter top in master bathroom and some new flooring. $54,900 $62,900 510 N 7th St, Petersburg Income potential! These 4 apartments are always full! They are well kept and located in a convenient setting close to town. At $490 per month you gross over $23,000 a year. These 2 bedroom apartments each have a 1 car garage and a concrete drive. Ideal setting for renters! MLS#193720 $189,900 1501 E Main St, Petersburg for lease Nice one story house located on Main St. in Petersburg. This home has a new roof, fireplace and plenty of charm. Property includes a double lot. 1403 Cedar St, Evansville Very nice well-maintained 1-bedroom home near Cedar Hall School. Quick access to Diamond Avenue and shopping areas. Very comfortable living at a very affordable price! A must-see property! Call Darron Albin at 483-6708 MLS# 195812 back on the market! MLS#191269 2102 E Main St., Petersburg Here is a turn key operation to be your own boss. The East Main Diner. A full service restaurant, grill, pizza parlor, and ice cream shop, fully equipped and ready to go. A clean and neat place. Beautifully rebuilt in 2008. High traffic area.. MLS#188436 $79,900 $34,000 618 E Main St, Petersburg Over 7,200 square feet and endless possibilities. Lots of room and space with over twenty rooms on the main level including a 60' x 45' lobby, at least seven large offices, a conference room, three bathrooms and much more. You double the space on the second floor. This also includes a 105' x 105' extra lot for parking. MLS#192716 $69,900 $35,900 8th St, Petersburg Over 2,100 sq. ft. free standing brick commercial building with plenty of parking and nice layout. To apply, call 812-380-1065 lots and acreage 4727 S Old SR 64, Winslow Fantastic 18 acres with a custom 68 X 40 Pole frame, wood sided barn. Acreage includes approximately 5 acres of open area with a pond and approximately 13 rolling acres of woods. Small shed located on the property will be removed by Owner. Call Joe Schitter at 449-6469 MLS#194268 $140,000 0 CR 100 S, Winslow 14.35 acres off Sugar Ridge Road on CR 100 S. This property has been used for agricultural and recreational. It has several nice building sites on the property. Pike Gibson and Duke are to the property. MLS#189843 $49,900 908 E Mona St, Petersburg Very nice 120' x 60' lot with utilities to the property. MLS#191341 $4,500 1605 E. Locust St., Petersburg 58'x105' lot at 1605 E. Locust. Nice lot in good neighborhood, convenient location near Petersburg Elementary. MLS#175379 $4,000 408 S 16th St, Petersburg Nice corner lot in a convenient location near Petersburg Elementary at the intersection of 16th and Maple Street. Dimensions are 52' x 105'. MLS#188796 $3,500